abstract：UNLABELLED:Patients with giant cell arteritis (GCA) refractory to standard immunosuppressive therapy may constitute a significant clinical problem with a high risk of glucocorticoid-related adverse effects. OBJECTIVES:To evaluate efficacy and safety of cyclophosphamide for remission induction in GCA patients with pers...

journal_title：Clinical and experimental rheumatology

authors： Loock J,Henes J,Kötter I,Witte T,Lamprecht P,Schirmer M,Gross WL

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVES:To study the CD26 density on monocytes and CD4+ T-lymphocytes in steroid and DMARD-naïve, early rheumatoid arthritis (RA) patients and to analyse for correlations with disease activity, including long-term radiographic progression. METHODS:Forty patients with active, early steroid and DMARD naïve RA (<6 mon...

journal_title：Clinical and experimental rheumatology

authors： Ellingsen T,Hansen I,Thorsen J,Kuno Møller B,Tarp U,Jacobsen S,Lund Hetland M,Vestergaard A,Hørslev-Petersen K,Stengaard-Pedersen K

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVES:Evidence indicates that the hyperplasia and inflammation of synovial tissues are significantly related to the pathogenic process of ankylosing spondylitis (AS). Using a proteomics approach, we detected a significantly increased expression of alpha 1-anti-trypsin (ATA1) in synovial membranes of patients with ...

journal_title：Clinical and experimental rheumatology

authors： Sun S,Fang K,Zhao Y,Yan X,Chang X

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVES:To offer a second opinion on the recently published retrospective diagnosis of Cardinal Carlo de' Medici (1596-1666), a prominent member of the grand ducal family then ruling Tuscany. METHODS:Retrospective diagnosis of historical figures is difficult and at times controversial, even with modern technology. ...

journal_title：Clinical and experimental rheumatology

authors： Weisz GM,Matucci-Cerinic M,Albury WR,Lippi D

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVES:The health problems of patients with rheumatoid arthritis and fibromyalgia are mostly invisible to others, which can lead to a discrepancy between patients' and spouses' appraisals of the severity of the health problems. As a consequence, some patients may feel 'invalidation' from their spouse, such as not b...

journal_title：Clinical and experimental rheumatology

authors： Kool MB,van Middendorp H,Bijlsma JW,Geenen R

更新日期：2011-11-01 00:00:00

abstract：OBJECTIVES:To determine the prevalence of juvenile fibromyalgia syndrome (JFMS) in children with familial Mediterranean fever (FMF) and to evaluate quality of life (QoL) and depression. METHODS:Ninety-one FMF patients (M/F: 44/47) who fulfilled the Livneh criteria and 60 healthy children (M/F: 27/33) were enrolled in ...

journal_title：Clinical and experimental rheumatology

authors： Alayli G,Durmus D,Ozkaya O,Sen HE,Genc G,Kuru O

更新日期：2011-11-01 00:00:00

abstract：OBJECTIVES:To examine the feasibility and efficacy of a multidisciplinary health care programme for patients with knee OA. METHODS:A 12-month follow-up care programme for knee OA, based on clinical evidence and expert opinion was implemented in primary care settings. It included recommendations on diagnosis, managemen...

journal_title：Clinical and experimental rheumatology

authors： Loza E,Benito-Ruiz P,Blanco F,de Miguel E,Román JA,ARTROACAS study group, Spain.

更新日期：2011-11-01 00:00:00

abstract：OBJECTIVES:Posterior ligaments of the sacroiliac joints (SIJ) are comprised of the long and the short posterior sacroiliac ligaments. They are recognised as a potential source of aspecific low back pain or peripartum pelvic pain. The aim of this study was to assess the characteristics of these ligaments using high reso...

journal_title：Clinical and experimental rheumatology

authors： Le Goff B,Berthelot JM,Maugars Y

更新日期：2011-11-01 00:00:00

abstract：OBJECTIVES:To compare salivary cytokine profiles in patients with primary Sjögren's syndrome (pSS), non-SS sicca controls, and non-sicca controls, and to investigate whether cytokine levels are correlated with clinical parameters of pSS patients. METHODS:Un-stimulated whole saliva samples were obtained from pSS patien...

journal_title：Clinical and experimental rheumatology

authors： Kang EH,Lee YJ,Hyon JY,Yun PY,Song YW

更新日期：2011-11-01 00:00:00

abstract：OBJECTIVES:To investigate systemic inflammation and autoimmune response to citrullinated peptides in patients with erosive and non erosive 'lone' hand osteoarthritis (HOA) with no hip/knee involvement and their relationship with radiographic structural damage. METHODS:Sera were obtained from a total of 99 patients wit...

journal_title：Clinical and experimental rheumatology

authors： Dolzani P,Assirelli E,Pulsatelli L,Addimanda O,Mancarella L,Peri G,Mantovani A,Facchini A,Meliconi R

更新日期：2011-11-01 00:00:00

abstract：OBJECTIVES:To investigate the role of elastosonography to improve the reliability of the ultrasound in the measurement of the dermal thickness at finger level in systemic sclerosis (SSc). METHODS:Twenty-two patients with a diagnosis of SSc were consecutively recruited. In all patients at the second finger level of the...

journal_title：Clinical and experimental rheumatology

authors： Di Geso L,Filippucci E,Girolimetti R,Tardella M,Gutierrez M,De Angelis R,Salaffi F,Grassi W

更新日期：2011-11-01 00:00:00

abstract：:Etanercept is a recombinant soluble tumour necrosis factor alpha receptor administered subcutaneously at the dose of 50 mg weekly (or 25 mg/twice weekly) for the treatment of the main chronic arthritides: rheumatoid arthritis and spondyloarthropathies. It shows high qualities in terms of efficacy and manageability. Fa...

journal_title：Clinical and experimental rheumatology

authors： Palazzi C,D'Angelo S,Cantini F,Lubrano E,Marchesoni A,Mathieu A,Salvarani C,Scarpa R,Spadaro A,Olivieri I

更新日期：2011-09-01 00:00:00

abstract：:The investigation of the hypothalamicpituitary-adrenal (HPA) axis in chronic inflammation has demonstrated: 1) an anti-inflammatory influence of the HPA axis; 2) low serum levels of adrenal androgen; 3) equivocal results with respect to levels of adrenocorticotropic hormone and cortisol; 4) inadequately low secretion ...

journal_title：Clinical and experimental rheumatology

authors： Straub RH,Buttgereit F,Cutolo M

更新日期：2011-09-01 00:00:00

abstract：:This paper in short reviews general indications, doses and routes of administration of glucocorticoid therapy in rheumatology. It presents greater detail concerning intralesional and intra-articular glucocorticoid injections. ...

journal_title：Clinical and experimental rheumatology

authors： Jacobs JW,Bijlsma JW

更新日期：2011-09-01 00:00:00

abstract：:Spondyloarthritides (SpA) are chronic inflammatory rheumatic diseases that usually affect the axial skeleton and may involve entheses and peripheral joints. The main subtypes are ankylosing spondylitis (AS) and psoriatic arthritis (PsA). Other subtypes are reactive arthritis, arthritis associated with chronic inflamma...

journal_title：Clinical and experimental rheumatology

authors： Fendler C,Baraliakos X,Braun J

更新日期：2011-09-01 00:00:00

abstract：OBJECTIVES:To compare the impact of ankylosing spondylitis (AS) on health-related quality of life (HRQL) and of adalimumab on initial and sustained improvement in HRQL for patients with active AS versus the general US population. METHODS:Data from the 5-year ATLAS trial were analysed. HRQL burden of AS and treatment i...

journal_title：Clinical and experimental rheumatology

authors： Kimel M,Revicki D,Rao S,Fryback D,Feeny D,Harnam N,Thompson C,Cifaldi M

更新日期：2011-07-01 00:00:00

abstract：OBJECTIVES:Although oligoarticular juvenile idiopathic arthritis (oJIA) is considered to carry the best prognosis among the JIA subtypes, many children evolve to a chronic course. A few studies have identified clinical risk factors for disease extension, and recent studies have evaluated synovial fluid markers. However...

journal_title：Clinical and experimental rheumatology

authors： Stoll ML,Li QZ,Zhou J,Punaro M,Olsen NJ

更新日期：2011-07-01 00:00:00

abstract：:Behçet's syndrome is a chronic multisystem inflammatory disease characterised classically by recurrent oral and genital ulcers with ocular lesions. It can affect blood vessels of all sizes, but involves veins more commonly than arterie. The presence of chylothorax in Behçet's syndrome is rare, with only a few cases ci...

journal_title：Clinical and experimental rheumatology

authors： Al Jaaly E,Baig K,Patni R,Anderson J,Haskard DO

更新日期：2011-07-01 00:00:00

abstract：OBJECTIVES:Advanced glycation end products (AGEs) have been implicated in the pathogenesis of bone-destructive disorders. Yet reports on the influence of AGEs on human osteoblasts remain lacking. The aim of the study is to investigate the influence of AGE-modified bovine serum albumin (AGE-BSA) on cell growth and expre...

journal_title：Clinical and experimental rheumatology

authors： Franke S,Rüster C,Pester J,Hofmann G,Oelzner P,Wolf G

更新日期：2011-07-01 00:00:00

abstract：OBJECTIVES:To describe the MRI features of gout tophi in the soft-tissues or joints of the limbs by low-field extremity-dedicated MRI. METHODS:Nine consecutive patients, 8M/1W, affected by chronic tophaceous gout were studied. Mean patients' age was 71.3±11.5 years, mean disease duration 98.1±44.9 months, and mean ser...

journal_title：Clinical and experimental rheumatology

authors： Paparo F,Zampogna G,Fabbro E,Parodi M,Andracco R,Ferrero G,Garlaschi G,Cimmino MA

更新日期：2011-05-01 00:00:00

abstract：OBJECTIVES:The burden of depressive symptoms and how demographic and disease characteristics relate to depressive symptoms in patients with rheumatoid arthritis (RA) that belong to developing populations, are currently unknown and were therefore assessed in a case-control study in public healthcare patients in South Af...

journal_title：Clinical and experimental rheumatology

authors： Solomon A,Christian BF,Woodiwiss AJ,Norton GR,Dessein PH

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:A recent study showed that the level of soluble Vascular Cell Adhesion Molecule 1 (VCAM-1) emerged as a strong and independent predictor of the risk of hip and knee joint replacement due to severe osteoarthritis (OA). Therefore, we hypothesized that soluble VCAM-1 level can be associated with prevalence and ...

journal_title：Clinical and experimental rheumatology

authors： Kalichman L,Pantsulaia I,Kobyliansky E

更新日期：2011-05-01 00:00:00

abstract：OBJECTIVES:This study was intended to verify the likelihood of homing of intra-articularily injected mesenchymal stem cells (MSCs) and its involvement in the healing process of experimentally induced, acute and chronic, partial chondral defects in dogs. METHODS:Partial thickness chondral defects were created on the la...

journal_title：Clinical and experimental rheumatology

authors： Mokbel A,El-Tookhy O,Shamaa AA,Sabry D,Rashed L,Mostafa A

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVES:Patients diagnosed with systemic sclerosis (SSc) report a high need for education and support. To address these needs, a short, group-based psycho-educational programme for patients with SSc was developed and evaluated. METHODS:A pre-post test design was utilised. Participants completed questionnaires on ph...

journal_title：Clinical and experimental rheumatology

authors： Kwakkenbos L,Bluyssen SJ,Vonk MC,van Helmond AF,van den Ende CH,van den Hoogen FH,van Lankveld WG

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVES:To evaluate the usefulness of neuropsychological tests in order to distinguish the first-choice methods useful in quick detection of cognitive impairment in SLE and preliminary diagnosis of neuropsychiatric manifestation. Study aimed at assessment of the prevalence and severity of cognitive deficits in SLE p...

journal_title：Clinical and experimental rheumatology

authors： Nowicka-Sauer K,Czuszynska Z,Smolenska Z,Siebert J

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVES:To evaluate the psychometric properties of the OARSI-OMERACT questionnaires in comparison to the existing validated scales. METHODS:Consecutive hip or knee osteoarthritis patients consulting in an orthopedic department were enrolled in the study. Data collected were pain using the Intermittent and Constant ...

journal_title：Clinical and experimental rheumatology

authors： Ruyssen-Witrand A,Fernandez-Lopez CJ,Gossec L,Anract P,Courpied JP,Dougados M

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVES:To evaluate an Ankylosing Spondylitis-specific Arthritis Self-Efficacy Scale (ASES-AS) United Kingdom (UK) secondary care population. METHODS:The ASES-AS is based on the 8-item ASES with minor alterations in phraseology. Patients from ten secondary care rheumatology centres across England were asked to comp...

journal_title：Clinical and experimental rheumatology

authors： Sandhu J,Packham JC,Healey EL,Jordan KP,Garratt AM,Haywood KL

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVES:To study the effects of antirheumatic drugs on hypothalamic-pituitary-adrenal (HPA) axis activity in patients with rheumatoid arthritis (RA). METHODS:Twenty patients with recent-onset active RA were studied before antirheumatic treatment, after 2 weeks of naproxen, and after 5½ months of additional treatmen...

journal_title：Clinical and experimental rheumatology

authors： Eijsbouts AM,Kempers MJ,van den Hoogen FH,Laan RF,Hermus AR,Ross HA,Sweep FC,van de Putte LB

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVES:Our aim was to assess long-term efficacy and tolerability of etanercept and infliximab in patients with JIA. METHODS:This was an observational, retrospective study of 41 patients treated with anti-TNF therapy. We assessed clinical remission, flare, ACR improvement, improvement of DAS28, and JADAS. Some pati...

journal_title：Clinical and experimental rheumatology

authors： Lamot L,Bukovac LT,Vidovic M,Frleta M,Harjacek M

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVES:To determine the prevalence of fibromyalgia (FM) in ankylosing spondylitis (AS). To evaluate the effect of FM on the measures of activity in AS. To analyse predictive factors in order to identify this group of patients. PATIENTS AND METHODS:A cross-sectional study based on 462 patients with definite ankylos...

journal_title：Clinical and experimental rheumatology

authors： Almodóvar R,Carmona L,Zarco P,Collantes E,González C,Mulero J,Sueiro JL,Gratacós J,Torre-Alonso JC,Juanola X,Batlle E,Ariza R,Font P

更新日期：2010-11-01 00:00:00

abstract：:Fibromyalgia (FM) is a common syndrome characterised by widespread pain and at least 11/18 painful tender points that requires multimodal pharmacological treatment also combined with non-pharmacological therapy. Various drugs currently are available to control the complex and different symptoms reported by patients. O...

journal_title：Clinical and experimental rheumatology

authors： Di Franco M,Iannuccelli C,Atzeni F,Cazzola M,Salaffi F,Valesini G,Sarzi-Puttini P

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:Adipose tissue-derived leptin and adiponectin control hunger, energy expenditure, insulin sensitivity, endothelial function, reproduction and immunity and are thought to play a role in autoimmune diseases. However, their role in ankylosing spondylitis (AS) is not clearly defined. Tumour necrosis factor ΤNF-α...

journal_title：Clinical and experimental rheumatology

authors： Derdemezis CS,Filippatos TD,Voulgari PV,Tselepis AD,Drosos AA,Kiortsis DN

更新日期：2010-11-01 00:00:00

abstract：OBJECTIVES:To analyse clinical severity/activity of rheumatoid arthritis (RA) according to smoking status. METHODS:The QUEST-RA multinational database reviews patients for Core Data Set measures including 28 swollen and tender joint count, physician global estimate, erythrocyte sedimentation rate (ESR), HAQ-function, ...

journal_title：Clinical and experimental rheumatology

authors： Naranjo A,Toloza S,Guimaraes da Silveira I,Lazovskis J,Hetland ML,Hamoud H,Peets T,Mäkinen H,Gossec L,Herborn G,Skopouli FN,Rojkovich B,Aggarwal A,Minnock P,Cazzato M,Yamanaka H,Oyoo O,Rexhepi S,Andersone D,Baranaus

更新日期：2010-11-01 00:00:00

abstract：OBJECTIVES:To determine the protein expression of TNFAIP3 in synovium and to show the capability of 6q23 intergenic SNPs, associated with rheumatoid arthritis (RA) susceptibility, to influence TNFAIP3 gene transcription. METHODS:Immunohistochemistry for TNFAIP3, NF-kB p65 and phosphorylated NF-kB p65 protein expressio...

journal_title：Clinical and experimental rheumatology

authors： Elsby LM,Orozco G,Denton J,Worthington J,Ray DW,Donn RP

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVES:Medical follow-up in the most appropriate treatment setting is important for patients with juvenile idiopathic arthritis (JIA). The aims of this study were 1) to identify the settings in which JIA patients are followed up after leaving paediatric rheumatology, and 2) to compare the clinical profile of patien...

journal_title：Clinical and experimental rheumatology

authors： Hilderson D,Corstjens F,Moons P,Wouters C,Westhovens R

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Vitamin D is a steroid hormone with important skeletal and non-skeletal biologic functions. Vitamin D deficiency is common and manifests with musculoskeletal symptoms. In rheumatoid arthritis (RA), vitamin D deficiency may be associated with increased disease activity and disability. We aimed ...

journal_title：Clinical and experimental rheumatology

authors： Haque UJ,Bartlett SJ

更新日期：2010-09-01 00:00:00

abstract：:The clinical relevance of the concept of bioavailability rests on two main principles. First, that measurement of the active component at the site of action is generally not possible and, secondly, that a relationship exists between on the one hand efficacy and/or safety and on the other hand concentration of the acti...

journal_title：Clinical and experimental rheumatology

authors： van Roon EN,van de Laar MA

更新日期：2010-09-01 00:00:00

abstract：:Low-dose methotrexate (MTX) remains the first-line treatment option among the disease-modifying antirheumatic drugs in patients with rheumatoid arthritis. However, diverse side effects are the major reason for MTX withdrawal and change of treatment. The following article reviews the published data on general and organ...

journal_title：Clinical and experimental rheumatology

authors： Albrecht K,Müller-Ladner U

更新日期：2010-09-01 00:00:00

abstract：:Methotrexate (MTX) is one of the immunosuppressants commonly used in inflammatory bowel diseases. There is very good evidence for its use in patients with steroid-dependent or steroid-refractory Crohn's disease for induction as well as maintenance of remission. Optimal dose as well as mode of application is still a ma...

journal_title：Clinical and experimental rheumatology

authors： Preiss JC,Zeitz M

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVES:To investigate carpal tunnel syndrome (CTS) with ultrasound (US) in asymptomatic SSc patients and to seek out the relationship between CTS and SSc clinical variables METHODS:In 64 SSc patients (55 women and 9 men, mean age 57±14 years) and in 30 healthy controls, area (MNA), transverse (MNT) and anteroposte...

journal_title：Clinical and experimental rheumatology

authors： Bandinelli F,Kaloudi O,Candelieri A,Conforti ML,Casale R,Cammarata S,Grassiri G,Miniati I,Melchiorre D,Matucci-Cerinic M

更新日期：2010-09-01 00:00:00